'
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
6.8
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
Supplement Facts
Serving Size:  1 Softgel
Amount Per Serving
%DV
Calories
15
 
Total Fat
1.5 g
2%**
Saturated Fat 
0.5 g
3%**
Cholesterol
10 mg
3%
Fish Oilprovides 360 mg of Total Omega-3 Fatty Acids†comprising of:EPA (Eicosapentaenoic Acid)DHA (Docosahexaenoic Acid)Other Fatty Acids
1,200 mg (1.2 g)
***************

Top Medical Research Studies

8
Eicosapentaenoic acid alleviates knee pain
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Considers EPA's mixed effects
We explored the potential benefits of eicosapentaenoic acid (EPA) combined with l-serine in relieving chronic low-back and knee pain among adults. In a well-structured randomized, double-blind, placebo-controlled trial, we followed 120 participants who suffered from pain for over three months. They were divided into two groups: one received daily doses of 594 mg of l-serine and 149 mg of EPA, while the other group was given a placebo.

After eight weeks of treatment and a four-week follow-up, we observed pain relief improvements reported through various questionnaires. The results indicated that the combination of l-serine and EPA was effective in reducing pain in the lower back and knees, highlighting the significance of these components in managing chronic pain conditions. Though EPA was part of a combination treatment, its anti-inflammatory properties may offer a promising avenue for individuals suffering from knee pain specifically.

Our findings provide an encouraging perspective for those seeking alternatives for pain management. While the study combined l-serine with EPA, it became evident that these ingredients together can lead to meaningful relief for patients with persistent knee pain.
Read More
9
Eicosapentaenoic Acid Reduces Knee Pain
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Study explores combined supplement effects
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.

Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.

Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.

However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Read More
7
Krill oil improves knee OA symptoms
Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
Moderate efficacy of krill oil
We examined how krill oil, which contains eicosapentaenoic acid (EPA), impacts knee pain in adults suffering from mild to moderate osteoarthritis (OA). In a well-structured study, 235 participants were involved in a six-month, double-blind, placebo-controlled trial, allowing us to see the real effects of krill oil compared to a placebo.

The participants took either 4 grams of krill oil daily or a placebo, and we assessed their knee pain and function at the beginning, three months, and six months into the study. The results revealed that krill oil led to modest improvements in knee pain, stiffness, and physical function.

Although the study showed positive results, it's important to note that we couldn’t isolate the specific impacts of eicosapentaenoic acid alone, since it was part of a complex oil supplement. Overall, this suggests that krill oil could be a safe and beneficial option for managing knee OA symptoms, but specific effects of EPA remain unclear.
Read More

Most Useful Reviews

9.5
Relieved knee pain
My mother found relief from her knee pain with this excellent product.
Read More
8.8
Improved health
After purchasing at a significant discount, I’m very pleased with the quality and quantity. We've been taking three tablets daily for four months, and it has truly improved my health, reducing my knee pain.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
6.8
9
Eicosapentaenoic Acid Reduces Knee Pain
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Study explores combined supplement effects
We conducted a study to investigate how eicosapentaenoic acid (EPA), a component of omega-3 fatty acids, impacts knee pain in healthy adults over the age of 40 with persistent discomfort. The study was structured as a randomized, double-blind, controlled clinical trial, which means that participants were assigned to either an EPA product or a placebo without knowing which they were receiving.

Over eight weeks, we observed four different groups: those taking pure EPA, those on a blend of EPA and another supplement, those on just the other supplement, and a placebo group. Our findings revealed that participants who consumed the EPA-based product experienced significant reductions in pain as measured by a visual analog scale (VAS), with the most noticeable improvements at the end of the eight weeks.

Additionally, the use of EPA seemed to enhance the quality of life by improving overall function and even aiding in better sleep quality. We also noted that the time taken to complete mobility tasks improved after the use of the EPA product. All participants reported safety, making EPA an appealing option for managing knee pain.

However, it’s important to note that the study included a combination of supplements, making it difficult to isolate the specific effects of just the eicosapentaenoic acid. Despite this, we feel confident in stating that incorporating EPA could be beneficial for those struggling with knee pain.
Read More
9
Eicosapentaenoic acid enhances knee pain relief
Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis.
Combination therapy relevance highlighted
We conducted a comprehensive study involving 177 patients with moderate to severe osteoarthritis (OA) affecting their hips or knees. Over 26 weeks, participants were divided into two groups. One group received glucosamine sulfate combined with omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The other group was treated with glucosamine sulfate alone.

Our main focus was to determine whether the combined treatment provided any notable benefits over glucosamine alone when it came to easing knee pain. We used the WOMAC score to assess pain, stiffness, and overall function in the participants. When we looked at the significant reduction of pain, more than 92% from both groups experienced some relief, but the combination treatment showed a higher response rate of 44%, compared to 32% in the glucosamine-only group.

Although both treatments appeared safe over the study duration, the statistical differences indicate that adding omega-3s can be beneficial for those specifically hoping for greater relief. We also noted that symptoms like morning stiffness and knee pain showed improvements, with greater reductions in the group taking the combination treatment. This suggests that eicosapentaenoic acid may provide added value in managing knee pain due to osteoarthritis, particularly for patients looking to maximize their treatment benefits.
Read More
8
Eicosapentaenoic acid alleviates knee pain
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Considers EPA's mixed effects
We explored the potential benefits of eicosapentaenoic acid (EPA) combined with l-serine in relieving chronic low-back and knee pain among adults. In a well-structured randomized, double-blind, placebo-controlled trial, we followed 120 participants who suffered from pain for over three months. They were divided into two groups: one received daily doses of 594 mg of l-serine and 149 mg of EPA, while the other group was given a placebo.

After eight weeks of treatment and a four-week follow-up, we observed pain relief improvements reported through various questionnaires. The results indicated that the combination of l-serine and EPA was effective in reducing pain in the lower back and knees, highlighting the significance of these components in managing chronic pain conditions. Though EPA was part of a combination treatment, its anti-inflammatory properties may offer a promising avenue for individuals suffering from knee pain specifically.

Our findings provide an encouraging perspective for those seeking alternatives for pain management. While the study combined l-serine with EPA, it became evident that these ingredients together can lead to meaningful relief for patients with persistent knee pain.
Read More
7
Krill oil improves knee OA symptoms
Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
Moderate efficacy of krill oil
We examined how krill oil, which contains eicosapentaenoic acid (EPA), impacts knee pain in adults suffering from mild to moderate osteoarthritis (OA). In a well-structured study, 235 participants were involved in a six-month, double-blind, placebo-controlled trial, allowing us to see the real effects of krill oil compared to a placebo.

The participants took either 4 grams of krill oil daily or a placebo, and we assessed their knee pain and function at the beginning, three months, and six months into the study. The results revealed that krill oil led to modest improvements in knee pain, stiffness, and physical function.

Although the study showed positive results, it's important to note that we couldn’t isolate the specific impacts of eicosapentaenoic acid alone, since it was part of a complex oil supplement. Overall, this suggests that krill oil could be a safe and beneficial option for managing knee OA symptoms, but specific effects of EPA remain unclear.
Read More
4
Eicosapentaenoic acid and knee pain
Effects of n-3 polyunsaturated fatty acid supplementation on quadriceps weakness immediately after total knee arthroplasty: a pilot, randomized, open-label clinical trial.
Moderate relevance to knee pain
In our quest to understand the role of eicosapentaenoic acid (EPA) in managing knee pain after total knee arthroplasty, we conducted a study involving 20 patients. We formed two groups—one receiving a daily supplement of EPA for 30 days before surgery, while the other received no supplement. This allowed us to observe how EPA could potentially affect both quadriceps strength and knee pain postoperatively.

Our findings revealed that the group taking the EPA showed a smaller increase in quadriceps weakness compared to those who did not receive the supplement. However, when we looked more closely at specific factors like knee pain during strength testing, we found that there were no significant differences between the two groups.

While EPA supplementation appears to have some advantages for quadriceps strength immediately after surgery, its effect on knee pain wasn’t as clear-cut. Overall, we observed that while EPA can influence quadriceps recovery, its impact on alleviating knee pain isn't strongly supported by our results.
Read More

User Reviews

USERS' SCORE
Excellent
Based on 2 Reviews
9.2
9.5
Relieved knee pain
My mother found relief from her knee pain with this excellent product.
8.8
Improved health
After purchasing at a significant discount, I’m very pleased with the quality and quantity. We've been taking three tablets daily for four months, and it has truly improved my health, reducing my knee pain.
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